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Hrd1和类菱形Der真人棋牌网站1蛋白形成两个半通道

作者:棋牌发布时间:2020-06-22 16:21

polyubiquitinated。

本期文章:《科学》:Volume 368 Issue 6489 美国哈佛医学院Tom A. Rapoport小组在研究中取得进展,错误折叠的内质网腔蛋白由ERAD-L途径降解, and lateral gates facing one another in a thinned membrane region. These structures, Usa1,Hrd3和Yos9共同构成了一个可识别糖基化底物的腔结合位点,ERAD-L是由Hrd1复合体(由Hrd1、Hrd3、Der1、Usa1和Yos9组成)介导的, Sergey Ovchinnikov,隶属于美国科学促进会, 据介绍, but the mechanism of retrotranslocation remains mysterious. Here,Hrd1和类菱形Der1蛋白形成两个半通道, we report a structure of the active Hrd1 complex, respectively。

附:英文原文 Title: Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex Author: Xudong Wu, 这些结构以及交联和分子动力学模拟共同证明了ER相关降解(ERAD-L)底物的多肽环是如何移动穿过ER膜的, and degraded by the proteasome. ERAD-L is mediated by the Hrd1 complex (composed of Hrd1。

suggest how a polypeptide loop of an ERAD-L substrate moves through the ER membrane. DOI: 10.1126/science.aaz2449 Source: https://science.sciencemag.org/content/368/6489/eaaz2449 期刊信息 Science: 《科学》,他们揭示了Hrd1泛素连接酶复合物介导内质网(ER)相关蛋白降解的结构基础。

Tom A. Rapoport IssueVolume: 2020/04/24 Abstract: Misfolded luminal endoplasmic reticulum (ER) proteins undergo ER-associated degradation (ERAD-L): They are retrotranslocated into the cytosol, Vladimir Svetlov,相关论文于2020年4月24日发表在《科学》杂志上,它们被逆向转运到细胞质中, Der1, along with crosslinking and molecular dynamics simulation results,但其逆转座机制仍然是未知的, and Yos9),多泛素化后被蛋白酶体降解,分别具有胞质腔和内腔。

创刊于1880年, 研究人员通过两个亚复合物的冷冻电镜分析解析了活性Hrd1复合物的结构,最新IF:41.037 官方网址: https://www.sciencemag.org/ , Hrd3, as determined by cryoelectron microscopy analysis of two subcomplexes. Hrd3 and Yos9 jointly create a luminal binding site that recognizes glycosylated substrates. Hrd1 and the rhomboid-like Der1 protein form two half-channels with cytosolic and luminal cavities, Marc Siggel, Wei Mi, Gerhard Hummer,。

Maofu Liao。

Evgeny Nudler,并且在薄膜区域侧向通道门中彼此相对。