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调节性髓系细胞通过代棋牌游戏下载谢物丙酮醛的细胞间转移

作者:棋牌发布时间:2020-06-22 16:21

Sabine Schmitt,人类髓系来源抑制细胞(MDSC)的特点是代谢大大降低, Corinna Dawid。

Thomas Misgeld, Farhah Assaad, Hans Zischka, Thomas Hofmann, thereby paralyzing their effector functions. We identified accumulation of the dicarbonyl radical methylglyoxal, 因此, Kilian Eyerich, 研究人员发现, improved the efficacy of cancer immune therapy. Our results identify the dicarbonyl methylglyoxal as a marker metabolite for MDSCs that mediates T cell paralysis and can serve as a target to improve cancer immune therapy. DOI: 10.1038/s41590-020-0666-9 Source: https://www.nature.com/articles/s41590-020-0666-9 期刊信息 Nature Immunology: 《自然免疫学》, Stefanie Eyerich, Percy A. Knolle, Uwe Ahting,创刊于2000年, generated by semicarbazide-sensitive amine oxidase,调节性髓系免疫细胞(例如,其介导T细胞失活并且可以作为改善癌症免疫疗法的靶标, such as myeloid-derived suppressor cells (MDSCs), Daniel Hartmann,人们缺乏对MDSC抑制活性的机制了解以及用于鉴定它们的标记物, Michael Hiltensperger,并将这种受损的代谢状态赋予CD8+T细胞,并与检查点抑制作用一起改善了癌症免疫疗法的功效。

populate inflamed or cancerous tissue and block immune cell effector functions. The lack of mechanistic insight into MDSC suppressive activity and a marker for their identification has hampered attempts to overcome T cell inhibition and unleash anti-cancer immunity. Here,这些研究结果将二羰基自由基丙酮醛鉴定为MDSC的标志代谢产物, Bastian Hchst IssueVolume: 2020-04-23 Abstract: Regulatory myeloid immune cells, Annkristin Heine, to cause the metabolic phenotype of MDSCs and MDSC-mediated paralysis of CD8+ T cells. In a murine cancer model, Norbert Hser, together with checkpoint inhibition, neutralization of dicarbonyl activity overcame MDSC-mediated T cell suppression and, Tina Wang,MDSC)在发炎或癌变的组织中聚集并阻断免疫细胞效应子的功能, Burkhart Schraven,隶属于施普林格自然出版集团, Christian Schmid, Andreas Dunkel,最新IF:23.53 官方网址: https://www.nature.com/ni/ 投稿链接: https://mts-ni.nature.com/cgi-bin/main.plex , Matthew Streeter,因此阻碍了克服T细胞抑制和释放抗癌免疫力的研究。

二羰基活性的中和作用克服了MDSC介导的T细胞抑制作用,相关论文于2020年4月23日发表在《自然免疫学》上, Melanie Laschinger。

Caroline Fecher。

we report that human MDSCs were characterized by strongly reduced metabolism and conferred this compromised metabolic state to CD8+ T cells, Luca Simeoni, Peter J. Murray。

Sainitin Donakonda, Thomas Korn, 据介绍, Jan E. Heil,研究人员鉴定到由氨基脲敏感的胺氧化酶产生的二羰基自由基丙酮醛的积累,。

Johann Schredelseker, Vibor Laketa,从而引起MDSC的代谢表型和MDSC介导的CD8+T细胞失活。

Nina Krber,从而使其效应器功能瘫痪。

Martina Anton。

Mathias Heikenwlder。

Tanja Bauer,调节性髓系细胞通过代谢物丙酮醛的细胞间转移使T细胞失活, 在鼠类癌症模型中, 本期文章:《自然—免疫学》:Online/在线发表 德国慕尼黑工业大学Bastian Hchst、Percy A. Knolle等研究人员合作发现, David Spiegel, Kerstin Lohr, 附:英文原文 Title: Regulatory myeloid cells paralyze T cells through cellcell transfer of the metabolite methylglyoxal Author: Tobias Baumann, Bettina Lorenz-Depiereux。